Nis in thyroid
WebDTC包括了乳头状甲状腺癌（papillary thyroid carcinoma，PTC）和滤泡状甲状腺癌（follicular thyroid carcinoma，FTC）。大多数DTC患者经过标准治疗（包括手术、 131 I治疗以及促甲状腺素抑制治疗）预后良好，但仍有部分发生局部复发和远处转移。 WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide …
Nis in thyroid
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WebOct 10, 2024 · Sodium-iodide symporter (NIS) (SLC5A5) is a transmembrane protein located in the basolateral membrane of thyroid follicular cells and enables iodine uptake by active transport (trapping) [ 5 ]. Human NIS glycoprotein consists of 643 amino acids, and the NIS gene is on chromosome 9. WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), and their regulators such as thyrotropin receptor (TSHR), thyroid transcription factor-1 (TTF-1), thyroid transcription …
WebMay 27, 1997 · NIS (Na + /I − symporter) is a key plasma membrane protein that catalyzes the active accumulation of iodide (I −) in the thyroid gland, a major step in the biosynthesis of thyroid hormones thyroxine (T 4) and tri-iodothyronine (T 3 ). WebFeb 11, 2024 · Thyroid nodules are solid or fluid-filled lumps that form within your thyroid, a small gland located at the base of your neck, just above your breastbone. Most thyroid nodules aren't serious and don't cause …
WebNational Center for Biotechnology Information WebJul 1, 2001 · In addition to its key role in thyroid physiology, NIS-mediated iodide accumulation in the thyroid gland is a crucial prerequisite for diagnostic scintigraphic imaging as well as for the highly efficient radioiodine therapy of benign and malignant thyroid diseases. The purpose of this review is to summarize and discuss the current …
WebApr 12, 2024 · We investigated the clinical significance of thyroid-stimulating hormone receptor (TSHR) mutations detected in thyroid fine needle aspiration (FNA) ... (NIS) mRNA was in the range of 0.01%–62.43% out of all sequencing reads, and was elevated in 49 (71%) cases. Surgical pathology follow-up was available in five cases (all benign except one). ...
WebDec 10, 2024 · It's usually based on the results of blood tests. The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone … java list to array of typeWebJun 9, 2010 · It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH). Although NIS mRNA … java list to array exampleWebOct 15, 2024 · We used three separate strategies to evaluate the potential NIS:NIS interaction, (i) co-IP assays, (ii) PLAs, and (iii) FRET assays, and utilized both a thyroid (SW1736) and nonthyroid (HeLa) cell line. First, we tagged NIS with either an HA or an MYC tag on the N- or C-terminus. low pass spitfireWebNov 22, 2024 · Despite NIS expression being retained in most DTCs, the levels of NIS and iodide uptake are reduced when compared to normal thyroid tissue . A defective NIS functional expression is the main reason for impaired iodide uptake and has been associated with several pathways linked to malignant transformation [ 6 ]. java list to comma separated stringWebNov 1, 2002 · The NIS is a membrane-bound glycoprotein cotransporter expressed by thyroid, salivary, gastric, mammary, and extraocular tissues (1–4).NIS is essential for the uptake of iodide and thyroid ... java list to string separated by commaWebThis assay investigates the transport of iodine via the NIS into the thyroid follicular cells. Chemicals can inhibit iodine uptake by competing with iodine for binding to the NIS … java list string to array stringWebThere are some mutations in the NIS DNA that cause hypothyroidism and thyroid dyshormonogenesis. Moreover, antibodies anti-NIS have been found in thyroid … java list to string with comma