Herg receptor
hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Zobacz więcej hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Zobacz więcej A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by … Zobacz więcej This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased channel function and drug-induced (acquired) long QT syndrome. Among the drugs that can cause QT prolongation, … Zobacz więcej HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Zobacz więcej Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem … Zobacz więcej Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment … Zobacz więcej The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human … Zobacz więcej Witryna5 lut 2024 · As a proof-of-concept study, we identified novel urotensin II receptor (UT) antagonists without hERG-blocking activity derived from a seed compound of a …
Herg receptor
Did you know?
Witrynainhibit hERG channels can cause LQTS (acquired or drug-induced LQTS) and an increased risk of Torsades de Pointes. This was first demonstrated in the late 1980s … WitrynaThe rapid component of the delayed rectifier potassium current, I(Kr), and the underlying hERG potassium channel are critical for the regulation of heart rhythm. Recent …
Witryna1 lip 1998 · Abstract. In the current study, the potential blocking ability of K + channels encoded by the human ether-a-go-go related gene (HERG) by the piperazine H 1 … Witryna1 cze 2024 · The first guideline defined hERG blockers with clog P > 1 or MW > 250. In this case, a range of Log D / P between ∼ -1 and ∼3.4 generally lead to compounds …
WitrynaIt is also worth noting that in the case of the hERG receptor, KM-408 showed 26.1% of control specific binding, which bodes well for the cardiovascular safety of tested … WitrynaHER2-receptorer. På overfladen af kroppens celler sidder såkaldte HER2-receptorer. HER2 står for human epidermal growth factor receptor 2. Normalt binder …
WitrynaE-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies [1] . E-4031 (0.1-10 μM) significantly depolarises the maximum diastolic …
WitrynaHERG-Kanal. Der hERG-Kanal (Abk. für engl. h uman E ther-a-go-go R elated G ene) ist ein spannungsaktivierter, auswärtsgleichrichtender Kaliumkanal in Herzmuskelzellen … soho palace theatreWitrynaThe main objective of this work was to collect and assess the hERG IC50 data available in accessible scientific literature to provide a high‐quality data set for further studies. … soho patternsWitryna1 gru 2014 · Heteromeric 1a/1b currents can be converted to 1a-like currents by coexpressing a fragment representing the PAS domain ().The PAS domain interacts … soho park restauranthttp://yadda.icm.edu.pl/yadda/element/bwmeta1.element.baztech-128c2fe7-9f5b-44a3-a8ed-a3b2f351d563 soho performance pantsWitrynaCell-surface proteins were biotinylated using sulfo-NHS-SS-biotin, purified with neutravidin beads from total cell lysates, subjected to SDS-PAGE and blotted onto a … slr magic 8mm f 4 reviewWitrynaThe highest peak in DRY-DRY auto correlogram in Figure 6 delineates the presence of two hydrophobic regions at a distance of 14.0–14.4 A° in virtual receptor site of … soho pedicureWitryna5 lis 2008 · Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties. … soho penny rounds