Gephyronic acid
WebIn this work we establish the activity and substrate preference for six MTs from the gephyronic acid polyketide synthase and demonstrate their ability to methylate both N-acetylcysteamine- and acyl carrier protein-linked β … WebJan 11, 2024 · Gephyronic acid, a cytostatic polyketide produced by the myxobacterium …
Gephyronic acid
Did you know?
WebAug 18, 2006 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid. Angewandte Chemie International Edition 2011, 50 (4) , 942-945. DOI: 10.1002/anie.201005605. Holly A. Reichard, Martin McLaughlin, Ming Z. Chen, Glenn C. Micalizio. ... WebSynthesis and Biological Evaluation of Gephyronic Acid Derivatives: Initial Steps towards the Identification of the Biological Target of Polyketide Inhibitors of Eukaryotic Protein Synthesis. European Journal of Organic Chemistry 2011, 2011 (36) , 7294-7307.
WebFeb 7, 2007 · Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid. Angewandte Chemie International Edition 2011, 50 (4) , 938-941. DOI: 10.1002/anie.201005530. WebTheoretical study on substrate recognition and catalytic mechanisms of gephyronic acid …
WebGephyronic acid also showed a cytostatic effect in mam-malian cell cultures (Table 2). The IC50 values varied from 10 to 60ng/ml. The hemiacetal was also tested against different fungi and the mouse cell line L929, but there was no significant difference between both forms of gephyronic acid concerning their biological activities in these assays. WebLa Biblioteca Virtual en Salud es una colección de fuentes de información científica y técnica en salud organizada y almacenada en formato electrónico en la Región de América Latina y el Caribe, accesible de forma universal en Internet de modo compatible con las bases internacionales.
WebTheoretical study on substrate recognition and catalytic mechanisms of gephyronic acid dehydratase DH1† Lei Liu , ‡ a Qian Yu , ‡ a Haoqing Zhang , a Wentao Tao , a Rufan Wang , a Linquan Bai , a Yi-Lei Zhao a … frayne construction plymouthWebAug 29, 2024 · Polyketide synthases (PKS) are a rich source of natural products of varied chemical composition and biological significance. Here, we report the characterization of an atypical dehydratase (DH) domain from the PKS pathway for gephyronic acid, an inhibitor of eukaryotic protein synthesis. Using a library of synthetic substrate mimics, the ... fray nata a freddyWebJan 7, 2024 · The structure and pathway annotation of gephyronic acid (Young et al., 2013) as well as initial biochemical characterization (Skiba et al., 2024) indicated that the GphF MT L converts Mal-ACP to Me 2 Mal-ACP via a MeMal-ACP intermediate (Figure 2 H). Thus, we tested the GphF GNAT selectivity for Me 2 Mal-ACP, MeMal-ACP and Mal … blender cheap free shippingWebAHAs and glycolic acid cause exfoliation of your skin. They remove the layer of surface … blender chauffant senya inox cook iceWebGyrophoric acid is a depside that can be found in the lichen Cryptothecia rubrocincta and … blender cheatWebMyxococcales. Les Myxococcales, ou Myxobacteria ou Myxobactéries, sont un ordre de bactéries que l'on trouve en majorité dans le sol et qui se nourrissent de composés organiques insolubles. Elles font partie de la classe des Deltaproteobacteria, un grand taxon de bactéries à Gram négatif. La plupart des myxobactéries connues se ... blender check coordinate of vertexWebSabine Laschat's 345 research works with 6,229 citations and 5,506 reads, including: Tailoring boron liquid crystals: Mesomorphic properties of iminodiacetic acid boronates frayne fashions florida