WebBackground: Platinum etoposide plus anti-programmed cell death ligand-1 (PD-L1) antibody therapy is the standard of care for extensive-stage small cell lung cancer (ES-SCLC). However, patient characteristics associated with the efficacy of the combination therapy in SCLC are unclear. Methods: We retrospectively reviewed post-surgical limited-stage … WebApr 4, 2024 · This high crossover rate likely provides an explanation for the flattening of the Kaplan-Meier curve observed with placebo plus chemotherapy, particularly among patients with PD-L1 TPS ≥ 1%, which was not observed in historical chemotherapy trials before the introduction of immunotherapy. 4 This crossover rate and plateauing of the Kaplan ...
PD-L1 in cancer: ESMO Biomarker Factsheet
WebSep 12, 2024 · Pembrolizumab significantly improved disease-free survival compared with placebo and was not associated with new safety signals in completely resected, PD-L1-unselected, stage IB–IIIA NSCLC. Pembrolizumab is potentially a new treatment option for stage IB–IIIA NSCLC after complete resection and, when recommended, adjuvant … WebApr 4, 2024 · Before the introduction of immune checkpoint inhibition therapy targeting programmed death protein 1 (PD-1) ligand (PD-L1), either given as single agent or in combination with chemotherapy, advanced non-small-cell lung cancer was uniformly fatal. These drugs have changed the treatment landscape for advanced non-small-cell lung … is amy adams a republican
Efficacy and safety of PD-1/PD-L1 inhibitor combined with chemotherapy …
WebOct 9, 2016 · Pembrolizumab vs. Chemotherapy for PD-L1–Positive Lung Cancer by means of blinded, independent, central radio - logic review, could cross over to receive pembro - lizumab, if safety criteria ... Web1 day ago · A study of Dato-DXd versus investigator’s choice chemotherapy in patients with locally recurrent inoperable or metastatic triple-negative breast cancer, who are not candidates for PD-1/PD-L1 ... WebPD-L1 or ‘programmed-death ligand 1’ (CD274), the main PD-1 ligand, is a transmembrane protein expressed on a variety of cell types, including antigen presenting cells, mainly dendritic cells and macrophages 3 … olph church buffalo ny